SUN-097 APOA1-MIMETIC PEPTIDES ENHANCE CELLULAR CLEARANCE OF CALCIPROTEIN PARTICLES AND ATTENUATE INFLAMMATORY PRIMING
نویسندگان
چکیده
منابع مشابه
Clearance of fetuin-A--containing calciprotein particles is mediated by scavenger receptor-A.
RATIONALE Fetuin-A is a liver-derived plasma protein involved in the regulation of calcified matrix metabolism. Biochemical studies showed that fetuin-A is essential for the formation of protein-mineral complexes, called calciprotein particles (CPPs). CPPs must be cleared from circulation to prevent local deposition and pathological calcification. OBJECTIVE We studied CPP clearance in mice an...
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15 صفحه اولApolipoprotein A-I mimetic peptides.
Despite identical amino acid composition, differences in class A amphipathic helical peptides caused by differences in the order of amino acids on the hydrophobic face results in substantial differences in antiinflammatory properties. One of these peptides is an apolipoprotein A-I (apoA-I) mimetic, D-4F. When given orally to mice and monkeys, D-4F caused the formation of pre-beta high-density l...
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ژورنال
عنوان ژورنال: Kidney International Reports
سال: 2020
ISSN: 2468-0249
DOI: 10.1016/j.ekir.2020.02.623